The science — graded, not hyped

A living, curated library of the evidence behind preparation and each medicine. Every entry is tagged for how strong the evidence actually is, and links to its source.

AllIbogaineMDMAKetaminePsilocybin / LSDCannabisKratomBrain terrainSafety of prep

Established consistent human evidencePromising early / mechanisticHypothesis being studied

Veteran outcomes & efficacy

Promising

Magnesium–ibogaine therapy improved disability, PTSD, depression & anxiety in 30 Special-Operations veterans with TBI (open-label). Cherian et al., Nature Medicine, 2024 · DOI

Promising

Psilocybin-assisted therapy significantly reduced heavy-drinking days in alcohol use disorder (RCT); no serious adverse events. Bogenschutz et al., JAMA Psychiatry, 2022 · DOI

Ibogaine — cardiac & pharmacology

Established

Iboga alkaloids block the cardiac hERG channel → QT prolongation & risk of fatal arrhythmia. Alper et al., Cardiovascular Toxicology, 2016 · DOI

Established

Ibogaine toxicity review: CYP2D6 metabolism, long-lived noribogaine, cardiac deaths, drug interactions. Litjens & Brunt, Clinical Toxicology, 2016 · DOI

Established

Cardiovascular complications — prolonged QT & ventricular arrhythmia; recommend CYP2D6 genotyping + monitoring. Brunt, Addiction, 2026 · DOI

Established

CYP2D6 poor-metabolizers get ~2× ibogaine exposure — genotype & halve the dose. Glue et al., J Clinical Pharmacology, 2015 · DOI

Other modalities

Established

MDMA & psilocybin raise blood pressure and heart rate — cardiovascular caution. Johnston et al., Am J Geriatric Psychiatry, 2022 · DOI

Established

Ketamine directly injures urothelial cells — the basis of "ketamine cystitis" with repeated use. Baker et al., American J Pathology, 2016 · DOI

Established

Cannabis use is associated with a dose-dependent increased risk of psychosis (review of reviews). Hasan et al., Eur Arch Psychiatry, 2019 · DOI

Established

Adverse effects of classic psychedelics (LSD/psilocybin): medical risk often low; HPPD, hypertension, abuse-liability examined. Schlag et al., J Psychopharmacology, 2022 · DOI

Established

Kratom carries risk of dependence, withdrawal, hepatotoxicity & life-threatening toxicity. Sethi et al., Prim Care Companion CNS Disord, 2020 · DOI

Brain terrain & neuroscience

Established

Blast exposure alters cerebral perfusion in military personnel — even without diagnosed TBI. Sullivan et al., JCBFM, 2020 · DOI

Established

Reduced cerebral blood flow tracks poorer white-matter integrity in veterans with TBI. Clark et al., NeuroImage: Clinical, 2016 · DOI

Established

Neurotoxic metals cross the blood–brain barrier and drive oxidative/inflammatory injury. Zahoor et al., Vitamins & Hormones, 2024 · DOI

Established

Environmental toxicants (metals, pesticides, solvents) contribute to neuroinflammation & cognitive decline. Pandics et al., GeroScience, 2023 · DOI

Promising

Neuroinflammation, microglia & reduced BDNF impair neuroplasticity (mechanistic review). Linnemann & Lang, Front. Pharmacology, 2020 · DOI

Promising

Psychedelics/psychoplastogens drive plasticity via BDNF-TrkB-mTOR + immunomodulation. Dolenec et al., Pharmaceuticals, 2026 · DOI

Safety of preparation

Established

Blood-metal levels poorly predict brain levels; chelating the non-overloaded caused lasting harm — test first, don't over-detox. Smith & Strupp, J Medical Toxicology, 2013 · DOI

A living library. Entries are curated and evidence-graded by the standards council; researchers can submit studies for review. This is the honest evidence base the whole standard is built on — and it will grow as the science moves. (Sample set shown; full library and submission portal are part of the build.)

Operation Whole Health — Patriot-founded 501(c)(3). Research Library — prototype page, DRAFT v0.1. Human evidence retrieved from PubMed; each entry links to its source.

Educational only; not medical advice. Substances referenced carry serious risks and vary in legality by jurisdiction. In crisis? Veterans Crisis Line: dial 988, then press 1.